Animal studies strongly suggest that alpha lipoic acid can alter thyroid hormone levels. Due to the lack of safety research, alpha-lipoic acid should not be used in children, pregnant women, or nursing mothers.
While considered safe, there are no guidelines directing the appropriate use of alpha-lipoic acid. Most oral supplements are sold in formulations ranging from to mg. Based on the bulk of the current evidence, a maximum daily dose of up to 1, mg is presumed to be safe in adults.
With that being said, everything from body weight and age to liver function and kidney function can impact what is safe for you as an individual. As a general rule of thumb, err on the side of caution and always opt for a lower dose.
Alpha lipoic acid supplements can be found online and in many health food stores and drugstores. For maximum absorption, the supplements should be taken on an empty stomach. As a dietary supplement, alpha-lipoic acid is not subject to strict regulation by the U. To ensure you are getting a quality supplement, opt for brands that have undergone voluntary testing by an independent certifying body like the U.
By doing so, you can be better assured that the supplements contain the listed ingredients and are manufactured to the highest quality standards. Alpha-lipoic acid is used to manage blood sugar associated with diabetes, spur weight loss, and ease neuropathy pain. ALA is also used in skincare and may help slow skin aging.
There is no evidence to confirm that ALA can help you sleep. In fact, insomnia can be a side effect of the supplement. However, ALA may help to reduce pain from neuropathy, which in theory may help people with the condition to sleep better.
ALA has anti-inflammatory properties. It may help to reduce systemic inflammation over time, but you will not notice any immediate effects. You don't need to get ALA from food. The body makes ALA through a series of biochemical processes involving fatty acids, proteins, and an enzyme known as lipoic acid synthase.
If you eat a nutritious diet, your body will have all the raw materials it needs to make alpha-lipoic acid. An alpha-lipoic acid deficiency is practically unheard of. Rare genetic mutations have been described in medical literature in which the body is unable to produce lipoic acid synthase. It is estimated that fewer than one of every 1,, people are affected. Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life.
Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases. Diabetol Metab Syndr. The effects of alpha-lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials.
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Alpha-lipoic acid ALA as a supplementation for weight loss: results from a meta-analysis of randomized controlled trials. Obes Rev. Effects of alpha-lipoic Acid on body weight in obese subjects. Most studies of oral alpha-lipoic acid have been small and poorly designed. One study did find that taking alpha-lipoic acid for diabetic neuropathy reduced symptoms compared to placebo. Taking alpha-lipoic acid may help another diabetes-related condition called autonomic neuropathy, which affects the nerves to internal organs.
One study of 73 people with cardiac autonomic neuropathy, which affects the heart, found that subjects reported fewer signs of the condition when taking mg of alpha-lipoic acid orally compared to placebo.
Because alpha-lipoic acid can pass easily into the brain, it may help protect the brain and nerve tissue. Researchers are investigating it as a potential treatment for stroke and other brain problems involving free radical damage, such as dementia. So far, there's no evidence to say whether or not it works. Preliminary studies suggest alpha-lipoic acid may help treat glaucoma.
But there is not enough evidence to say for sure whether it works. Studies show ALA binds with toxic metals, such as mercury, arsenic, iron, and other metals that act as free radicals. Preliminary studies also suggest that ALA may play a role in managing other conditions including erectile dysfunction and cancer. And preliminary studies suggest it may reduce complications associated with otitis media ear infections.
If you are healthy, your body makes enough alpha-lipoic acid. It is also found in red meat, organ meats such as liver , and yeast -- particularly brewer's yeast. Alpha-lipoic acid supplements are available as capsules. Your health care provider can also give it by injection. Pediatric Alpha-lipoic acid has not been studied in children, so it is not recommended for pediatric use. Check with your doctor regarding dosing recommendations. Studies are mixed about whether or not to take ALA with meals.
Because of the potential for side effects and interactions with medications, you should take dietary supplements only under the supervision of a health care provider.
Alpha-lipoic acid hasn't been studied in pregnant or breastfeeding women, so researchers don't know if it's safe. Alpha-lipoic acid can lower blood sugar levels, so people with diabetes or low blood sugar should take alpha-lipoic acid only under the supervision of their health care provider.
Animal studies suggest that people who don't get enough thiamine vitamin B1 should not take alpha-lipoic acid. B1 deficiency is associated with long-term alcohol abuse.
If you are being treated with any of the following medications, you should not use alpha-lipoic acid without first talking to your health care provider. Apha-lipoic acid can combine with these drugs to lower blood sugar levels, raising the risk of hypoglycemia or low blood sugar. Ask your provider before taking alpha-lipoic acid, and watch your blood sugar levels closely.
Your provider may need to adjust your medication doses. Alpha-lipoic acid may interfere with some chemotherapy medications. Mild effects may include nausea, rashes, and itching if a person takes high doses. According to researchers , adults may take it up to 2, milligrams without serious side effects. There is not enough research and evidence on the extra benefits and potential side effects of taking higher doses, so medical professionals do not recommend it.
There is not enough evidence on its safety for use in children, however, so adults should always keep ALA in a safe place. It is essential for people considering taking ALA supplements to talk to their doctor to see if it is right for them. ALA is an organic compound that acts as an antioxidant and has a variety of other effects on the body. While the body makes it naturally, some people also choose to take ALA supplements. Research suggests that ALA may help with weight loss, diabetes, memory loss, and some other health conditions.
However, there is not enough research to understand its full benefits or effectiveness in humans. ALA is generally safe for adults, but it is best to speak with a doctor before taking any new supplements. ALA supplements are available in some pharmacies, health food stores, and online.
Treatment for depression focuses on antidepressant medications, but some herbs and supplements may also help. These include St. John's wort, lavender….
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