They also found no signs of damage to the stomach lining following the injections, which penetrate about 4. Going forward with a view to human testing, the researchers acknowledged that significant clinical development will be required to evaluate safety and effectiveness. In doing so, it can provide a less intrusive route of administration for drugs that are otherwise limited to injectables. The investigators anticipate that in the future, patients may be able to orally take a diverse array of medications that were once only available via needle.
This technological advancement could apply to chronic conditions that require regular dosing or to systems that are more episodic. Mass administration of an otherwise injectable drug also becomes much easier if it can be given orally. TFF Pharma has a thin film freezing technology that solves the problem a different way. Administration can be via inhalation to achieve similar absorption rates too. Log in to leave a comment. Sign in. Forgot your password?
Get help. Privacy Policy. Create an account. To lessen the risk, use the smallest effective dose for the shortest possible time. Babies born to mothers who use this drug for a long time may develop severe possibly fatal withdrawal symptoms. This medication is used to treat severe pain. Morphine belongs to a class of drugs known as opioid analgesics.
It works in the brain to change how your body feels and responds to pain. Depending on your specific product, this medication is given by injection into a vein, into a muscle, or under the skin. Use this product exactly as directed by your doctor. Read and learn all of the manufacturer's instructions for preparation and use.
If you have any questions about using this medication properly, consult your doctor or pharmacist. Preservative-free morphine may also be given by a doctor as an injection into the area around the spinal cord epidural or into the fluid-filled space that contains the spinal cord intrathecal. In this case, the medication is first given in the hospital where you can be monitored closely.
If your doctor directs you to continue using this medication at home, it is usually given as a continuous injection using an infusion pump placed under your skin. The dosage is based on your medical condition and response to treatment. For children, the dosage may also be based on weight. Do not increase your dose, use the medication more frequently, or use it for a longer time than prescribed.
Properly stop the medication when so directed. Pain medications work best if they are used when the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Before injecting each dose, clean the injection site with rubbing alcohol.
If this medication is given into a muscle or under the skin, it is important to change the location of the injection site with each dose to avoid problem areas under the skin. Learn how to store and discard needles and medical supplies safely. Consult your pharmacist for more details.
If nausea occurs, consult your doctor or pharmacist for ways to decrease it such as lying down for 1 to 2 hours with as little head movement as possible. Suddenly stopping this medication may cause withdrawal, especially if you have used it for a long time or in high doses. To prevent withdrawal, your doctor may lower your dose slowly.
When this medication is used for a long time, it may not work as well. Your doctor may need to increase your dose or change your medication. Talk with your doctor if this medication stops working well. Though it helps many people, this medication may sometimes cause addiction.
Use this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details. Nausea, vomiting, constipation, lightheadedness, dizziness, drowsiness, increased sweating, or dry mouth may occur.
Pain, redness, or swelling at the injection site may occur if this medication is given into a muscle or under the skin. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To prevent constipation, eat dietary fiber, drink enough water, and exercise. You may also need to take a laxative. Ask your pharmacist which type of laxative is right for you. To lower your risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:. If we can make it easier for patients to receive their medication, we can help maximize drug adherence or compliance," said C.
The researchers designed the L-SOMA so that it can be loaded with up to 4 mg doses of a desired medication. The pill contains a retractable needle that injects the treatment directly into tissue within the stomach. This innovation expands upon the developed technology by enabling the device to work with liquid medications that need to be absorbed more quickly or are challenging to formulate as solids.
They then collected blood samples from each of the animals and found that the L-SOMA pill delivered medications at comparable levels to those given with an injection. Going forward, researchers aim to test this technology in humans. They anticipate that in the future, patients may be able to orally take a diverse array of medications that were once only available via needle. Additionally, because of the L-SOMA's injectable nature, scientists believe that it has the potential to administer vaccines, including the COVID vaccine as well as potentially others.
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